A better way to discover gene function in the social amoeba Dictyostelium discoideum.
نویسنده
چکیده
Insight/Outlook The ethics of conducting molecular autopsies in cases of sudden death in the young 1165 Amy L. McGuire, Quianta Moore, Mary Majumder, Magdalena Walkiewicz, Christine M. Eng, John W. Belmont, Salma Nassef, Sandra Darilek, Katie Rutherford, Stacey Pereira, Steven E. Scherer, V. Reid Sutton, Dwayne Wolf, Richard A. Gibbs, Roger Kahn, Luis A. Sanchez, and the Molecular Autopsy Consortium of Houston (MATCH)
منابع مشابه
Relevant Genes Linked to Virulence Are Required for Salmonella Typhimurium to Survive Intracellularly in the Social Amoeba Dictyostelium discoideum
The social amoeba Dictyostelium discoideum has proven to be a useful model for studying relevant aspects of the host-pathogen interaction. In this work, D. discoideum was used as a model to study the ability of Salmonella Typhimurium to survive in amoebae and to evaluate the contribution of selected genes in this process. To do this, we performed infection assays using axenic cultures of D. dis...
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The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, severe neurodegenerative disorders also known as Batten disease. Juvenile NCL (JNCL) is caused by recessive loss-of-function mutations in CLN3, which encodes a transmembrane protein that regulates endocytic pathway trafficking, though its primary function is not yet known. The social amoeba Dictyostelium discoideum is increasing...
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Studies of chemotaxis in the social amoeba Dictyostelium discoideum have revealed numerous conserved signaling networks that are activated by chemoattractants. In the presence of a uniformly distributed stimulus, these pathways are transiently activated, but in a gradient they are activated persistently and can be localized to either the front or the back of the cell. Recent studies have begun ...
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The social amoeba Dictyostelium discoideum, a powerful paradigm provides clear insights into the regulation of growth and development. In addition to possessing complex individual cellular functions like a unicellular eukaryote, D. discoideum cells face the challenge of multicellular development. D. discoideum undergoes a relatively simple differentiation process mainly by cAMP mediated pathway...
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Inorganic polyphosphate (polyP) deficiency in enteric bacterial pathogens reduces their ability to invade and establish systemic infections in different hosts. For instance, inactivation of the polyP kinase gene (ppk) encoding the enzyme responsible for polyP biosynthesis reduces invasiveness and intracellular survival of Salmonella enterica serovar Typhimurium (S. Typhimurium) in epithelial ce...
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عنوان ژورنال:
- Genome research
دوره 26 9 شماره
صفحات -
تاریخ انتشار 2016